Endocrine Abstracts

Objective: Transforming growth factor beta receptor 3 like (TGFBR3L) has been recently described as a pituitary-specific membrane protein detected in a proportion of the gonadotroph cells in non-neoplastic and tumour tissue (1). Furthermore, mouse studies have indicated that TGFBR3L is an inhibin B co-receptor that regulates FSH levels (2). We hypothesized that TGFBR3L expression in gonadotroph non-functioning pituitary neuroendocrine tumours (NF-PitNETs) is related to clinica...

Introduction: The 2022 WHO classification identifies seven different pituitary tumour subtypes with growth hormone (GH) secretion and/or expression, with or without concurrent prolactin expression. The response to dopamine agonist (DA) treatment in these subtypes requires further investigation. The bromocriptine test has historically been a part of the acromegaly evaluation and may provide insights to DA treatment responsiveness. We aimed to explore the correlations between ba...

The clinical presentation of primary hyperparathyroidism (PHPT) has changed dramatically after increased accessibility to biochemical auto-analysers and the diagnosis is today often made by change in patients without specific symptoms. Operative treatment is recommended in patient with markedly increased calcium levels or typical symptoms. However, the vast majority of patients in the modern clinic do not present organ related symptoms and their calcium levels are only slightl...

The clinical presentation of primary hyperparathyroidism has changed dramatically after increased accessibility to biochemical auto-analysers and the diagnosis is today often made by change in patients without specific symptoms. Operative treatment is recommended in patient with markedly increased calcium levels or typical symptoms. However, the vast majority of patients in the modern clinic do not present organ related symptoms and their calcium levels are only slightly incre...

Primary Hyperparathyroidism (PHPT) is the most common disease among parathyroid disorders compared to Chronic Hypoparathyroidism, Calcium Sensor disorders (loss or gain of function mutations) or Parathyroid Cancer. The clinical presentation of PHPT has changed dramatically after the increased accessibility to biochemical analyses. The diagnosis is today often made by change in patients without specific symptoms. Operative treatment is always an option and recommended in patien...

Classification of pituitary neuroendocrine tumours (NETs) or pituitary adenomas is based on the expression of the anterior lobe pituitary hormones (FSH, LH, GH, Prolactin, TSH, ACTH and alpha-subunit of the glycoprotein hormones). Assessment of the transcription factors SF-1, Pit-1 and T-Pit has been a complement to the classification. Tumours negative for both pituitary hormones and transcription factors have been designated as null-cell adenomas. However, lack of sensitive a...

Background: Bone turnover is increased in active acromegaly. Despite normalization of bone turnover after treatment, the risk for vertebral fractures remains increased. Gonadal status, but not bone mineral density (BMD) is correlated to vertebral fracture incidence. Trabecular and cortical bone are differentially affected by GH and IGF-1. The trabecular bone score (TBS) is related to bone microarchitecture and provides further information not captured by BMD measurement.<p...

Objective: To investigate long-term effects of GH replacement therapy.Material and methods: Thirty-nine patients (mean age 52.5 years, 14 women) with adult-onset growth hormone deficiency (AOGHD), recruited from a randomized placebo-controlled crossover study of treatment with growth hormone (GH) and placebo for 9months each, were enrolled in an open prospective follow up study. GH replacement was given for additional thirty-three months and was individu...

Objective: Pasireotide is a second-generation somatostatin receptor ligands (SRLs) with highest affinity for somatostatin receptor (SST)5, followed by SST2. It is considered, so far, in patients resistant to first-generation SRLs, after surgical failure. Histological characteristics and T2-weighted MRI can predict resistance to first-generation SRLs in patients with somatotroph adenomas. Previous studies primarily assessed efficacy of pasireotide as 2nd or 3rd line medical tre...

Purpose: Clinically Non-Functioning Pituitary Neuroendocrine Tumours (NF-PitNETs) present a varying degree of aggressiveness, and reliable prognostic markers are lacking. We aimed to characterize the distribution of E- and N-cadherin in corticotroph, PIT1 and null-cell NF-PitNETs, and link it to the clinical course of the tumours.Methods: We investigated the distribution of E- and N-cadherin by immunohistochemistry in a retrospective cohort of thirty tum...